Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL834785

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration value against human colon carcinoma H-116 or human cancer HL-60 tumor cell line
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.
Maya AB, Pérez-Melero C, Mateo C, Alonso D, Fernández JL, Gajate C, Mollinedo F, Peláez R, Caballero E, Medarde M.
J Med Chem (2005) 48 : 556 -568
PubMed 15658869 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 6.12 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL180217 1 8.52
CHEMBL84903 1 7.80
CHEMBL451490 1 7.57
CHEMBL442784 1 7.46
CHEMBL78126 1 6.51
CHEMBL361539 1 6.48
CHEMBL175504 1 6.48
CHEMBL180024 1 6.47
CHEMBL3706761 1 6.47
CHEMBL176291 1 6.42
CHEMBL82612 1 6.41
CHEMBL369169 1 5.82
CHEMBL369756 1 5.56
CHEMBL180218 1 5.54
CHEMBL176130 1 5.54
CHEMBL176231 1 5.51
CHEMBL179670 1 5.51
CHEMBL175660 1 5.50
CHEMBL366738 1 5.49
CHEMBL175445 1 5.49
CHEMBL426770 1 5.45
CHEMBL367610 1 5.44
CHEMBL175431 1 5.44
CHEMBL1795038 1 5.44
CHEMBL175897 1 5.44
CHEMBL175834 1 5.30
CHEMBL175891 1 -
CHEMBL176943 1 -
CHEMBL176232 1 -
CHEMBL366613 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL180217 IC50 = 3.0 nM 8.52
CHEMBL84903 IC50 = 16.0 nM 7.80
CHEMBL451490 IC50 = 27.0 nM 7.57
CHEMBL442784 IC50 = 35.0 nM 7.46
CHEMBL78126 IC50 = 310.0 nM 6.51
CHEMBL361539 IC50 = 330.0 nM 6.48
CHEMBL175504 IC50 = 330.0 nM 6.48
CHEMBL180024 IC50 = 340.0 nM 6.47
CHEMBL3706761 IC50 = 340.0 nM 6.47
CHEMBL176291 IC50 = 380.0 nM 6.42
CHEMBL82612 IC50 = 390.0 nM 6.41
CHEMBL369169 IC50 = 1520.0 nM 5.82
CHEMBL369756 IC50 = 2750.0 nM 5.56
CHEMBL180218 IC50 = 2850.0 nM 5.54
CHEMBL176130 IC50 = 2880.0 nM 5.54
CHEMBL176231 IC50 = 3090.0 nM 5.51
CHEMBL179670 IC50 = 3090.0 nM 5.51
CHEMBL175660 IC50 = 3150.0 nM 5.50
CHEMBL175445 IC50 = 3230.0 nM 5.49
CHEMBL366738 IC50 = 3230.0 nM 5.49
CHEMBL426770 IC50 = 3590.0 nM 5.45
CHEMBL367610 IC50 = 3650.0 nM 5.44
CHEMBL175431 IC50 = 3620.0 nM 5.44
CHEMBL1795038 IC50 = 3650.0 nM 5.44
CHEMBL175897 IC50 = 3620.0 nM 5.44
CHEMBL175834 IC50 = 5000.0 nM 5.30
CHEMBL176059 IC50 > 5000.0 nM -
CHEMBL368232 IC50 > 5000.0 nM -
CHEMBL3706760 IC50 > 10000.0 nM -
CHEMBL175920 IC50 > 5000.0 nM -
CHEMBL179194 IC50 > 5000.0 nM -
CHEMBL175429 IC50 > 5000.0 nM -
CHEMBL177278 IC50 > 5000.0 nM -
CHEMBL368498 IC50 > 10000.0 nM -
CHEMBL85065 NAPHTHYLCOMBRETASTATIN IC50 > 5000.0 nM -
CHEMBL366613 IC50 > 5000.0 nM -
CHEMBL176232 IC50 > 5000.0 nM -
CHEMBL176943 IC50 > 5000.0 nM -
CHEMBL175891 IC50 > 5000.0 nM -