Assay Detail
Functional
CHEMBL834790
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Inhibitory concentration against gel filtered platelet aggregation induced by alpha thrombin
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.24 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361822 | — | — | 1 | 8.00 |
| CHEMBL368894 | — | — | 1 | 7.80 |
| CHEMBL368960 | — | — | 1 | 7.77 |
| CHEMBL368937 | — | — | 1 | 7.55 |
| CHEMBL179210 | — | — | 1 | 7.54 |
| CHEMBL270437 | — | — | 1 | 7.50 |
| CHEMBL367890 | — | — | 1 | 7.41 |
| CHEMBL176385 | — | — | 1 | 7.37 |
| CHEMBL435514 | — | — | 1 | 7.34 |
| CHEMBL368900 | — | — | 1 | 7.23 |
| CHEMBL176063 | — | — | 1 | 6.75 |
| CHEMBL272931 | — | — | 1 | 6.64 |
| CHEMBL180163 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361822 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL368894 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL368960 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL368937 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL179210 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL270437 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL367890 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL176385 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL435514 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL368900 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL176063 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL272931 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL180163 | — | IC50 | = | 5200.0 | nM | 5.28 |