Assay Detail
Functional
CHEMBL834886
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Inhibition constant against human recombinant carbonic anhydrase I
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.02 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL189065 | — | — | 1 | 7.47 |
| CHEMBL189729 | — | — | 1 | 7.44 |
| CHEMBL364903 | — | — | 1 | 7.31 |
| CHEMBL190622 | — | — | 1 | 7.16 |
| CHEMBL190392 | — | — | 1 | 7.16 |
| CHEMBL373325 | — | — | 1 | 7.16 |
| CHEMBL193199 | — | — | 1 | 7.16 |
| CHEMBL189113 | — | — | 1 | 7.16 |
| CHEMBL191799 | — | — | 1 | 7.15 |
| CHEMBL190314 | — | — | 1 | 7.14 |
| CHEMBL193191 | — | — | 1 | 7.11 |
| CHEMBL190447 | — | — | 1 | 7.04 |
| CHEMBL192997 | — | — | 1 | 7.04 |
| CHEMBL190448 | — | — | 1 | 7.03 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL189065 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL189729 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL364903 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL190622 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL190392 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL373325 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL193199 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL189113 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL191799 | — | Ki | = | 70.5 | nM | 7.15 |
| CHEMBL190314 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL193191 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL190447 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL192997 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL190448 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 28000.0 | nM | 4.55 |