Assay Detail
Functional
CHEMBL834967
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Effect on the increase in cAMP formation induced by PGD-2 in the presence of bovine serum albumin in CHO cells expressing mouse Prostaglandin D2 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of orally active prostaglandin D2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.66 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186735 | — | — | 1 | 7.30 |
| CHEMBL361457 | — | — | 1 | 6.92 |
| CHEMBL182555 | — | — | 1 | 6.52 |
| CHEMBL365243 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186735 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL361457 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL182555 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL365243 | — | IC50 | = | 1300.0 | nM | 5.89 |