Assay Detail
Functional
CHEMBL835019
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Concentration required for 50% protection of infected MT-4 cells from wtIIIB-HIV-1-induced cytopathogenicity was determined by the MTT method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Docking and 3-D QSAR studies on indolyl aryl sulfones. Binding mode exploration at the HIV-1 reverse transcriptase non-nucleoside binding site and design of highly active N-(2-hydroxyethyl)carboxamide and N-(2-hydroxyethyl)carbohydrazide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.33 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366702 | — | — | 1 | 9.00 |
| CHEMBL176239 | — | — | 1 | 9.00 |
| CHEMBL366914 | — | — | 1 | 8.00 |
| CHEMBL180522 | — | — | 1 | 8.00 |
| CHEMBL180330 | — | — | 1 | 6.89 |
| CHEMBL148987 | — | — | 1 | 6.00 |
| CHEMBL179469 | — | — | 1 | 5.64 |
| CHEMBL357793 | — | — | 1 | 5.40 |
| CHEMBL342760 | — | — | 1 | 5.30 |
| CHEMBL151377 | — | — | 1 | 5.22 |
| CHEMBL149104 | — | — | 1 | 4.96 |
| CHEMBL359306 | — | — | 1 | 4.80 |
| CHEMBL355999 | — | — | 1 | 4.13 |
| CHEMBL151810 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366702 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL176239 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL366914 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL180522 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL180330 | — | EC50 | = | 128.82 | nM | 6.89 |
| CHEMBL148987 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL179469 | — | EC50 | = | 2290.87 | nM | 5.64 |
| CHEMBL357793 | — | EC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL342760 | — | EC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL151377 | — | EC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL149104 | — | EC50 | = | 10964.78 | nM | 4.96 |
| CHEMBL359306 | — | EC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL355999 | — | EC50 | = | 74131.02 | nM | 4.13 |
| CHEMBL151810 | — | EC50 | = | 151356.12 | nM | - |