Assay Detail
Functional
CHEMBL835173
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In vitro inhibition of ADP-induced platelet aggregation in rat platelet rich plasma
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: orally active prostacyclin mimetics. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.67 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190497 | — | — | 1 | 6.20 |
| CHEMBL132589 | — | — | 1 | 5.92 |
| CHEMBL371571 | — | — | 1 | 5.66 |
| CHEMBL192990 | — | — | 1 | 5.30 |
| CHEMBL268477 | AP-227 | — | 1 | 5.25 |
| CHEMBL436131 | — | — | 1 | - |
| CHEMBL191257 | — | — | 1 | - |
| CHEMBL193018 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190497 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL132589 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL371571 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL192990 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL268477 | AP-227 | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL436131 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL191257 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL193018 | — | IC50 | > | 10000.0 | nM | - |