Assay Detail
Functional
CHEMBL835180
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In-vitro inhibitory concentration for human tumor HL60 cell-line was determined using SRB assay after 3 days of incubation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antitumor activity of the hexacyclic camptothecin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.30 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192692 | — | — | 1 | 9.55 |
| CHEMBL189205 | — | — | 1 | 8.52 |
| CHEMBL366213 | — | — | 1 | 8.51 |
| CHEMBL193278 | — | — | 1 | 8.38 |
| CHEMBL190617 | — | — | 1 | 8.31 |
| CHEMBL189108 | — | — | 1 | 8.15 |
| CHEMBL193123 | — | — | 1 | 8.08 |
| CHEMBL364308 | — | — | 1 | 8.06 |
| CHEMBL363863 | — | — | 1 | 8.04 |
| CHEMBL280320 | — | — | 1 | 7.96 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192692 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL189205 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL366213 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL193278 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL190617 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL189108 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL193123 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL364308 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL363863 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL280320 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 19.0 | nM | 7.72 |