Assay Detail
Functional
CHEMBL835220
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for growth inhibition of human colon carcinoma cell line HCT116
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.71 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.22 |
| CHEMBL418203 | — | — | 1 | 6.31 |
| CHEMBL370283 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL418203 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL370283 | — | IC50 | = | 2500.0 | nM | 5.60 |