Assay Detail
Functional
CHEMBL835236
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Inhibition concentration against ADP-induced platelet aggregation using rat platelet rich plasma
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.19 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268477 | AP-227 | — | 1 | 5.25 |
| CHEMBL195456 | — | — | 1 | 5.13 |
| CHEMBL426829 | — | — | 1 | - |
| CHEMBL196935 | — | — | 1 | - |
| CHEMBL197319 | — | — | 1 | - |
| CHEMBL196194 | — | — | 1 | - |
| CHEMBL371399 | — | — | 1 | - |
| CHEMBL425916 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268477 | AP-227 | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL195456 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL426829 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL196935 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL197319 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL196194 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL371399 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL425916 | — | IC50 | > | 10000.0 | nM | - |