Assay Detail
Functional
CHEMBL835244
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Concentration required for growth inhibition of human lymphoblastic leukemic cell line (CCRF-CEM) was determined
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent antitumor N-mustard derivatives of 9-anilinoacridine, synthesis and antitumor evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.67 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.92 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.82 |
| CHEMBL365915 | — | — | 1 | 8.52 |
| CHEMBL182739 | — | — | 1 | 8.15 |
| CHEMBL185119 | — | — | 1 | 7.70 |
| CHEMBL184802 | — | — | 1 | 7.05 |
| CHEMBL321473 | — | — | 1 | 6.12 |
| CHEMBL185256 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL365915 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL182739 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL185119 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL184802 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL321473 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL185256 | — | IC50 | = | 770.0 | nM | 6.11 |