Assay Detail
Functional
CHEMBL835446
Review assay metadata, readout intent, target linkage, and publication context from the same page.
pA2 for NK2 receptor of rabbit pulmonary artery
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of 1-alkyl-5-(3,4-dichlorophenyl)-5-{2-[3-(substituted)-1-azetidinyl]-ethyl}-2-piperidones. Part 2: Improving oral absorption.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 15 | 9.02 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434548 | — | — | 1 | 10.10 |
| CHEMBL367815 | — | — | 1 | 9.70 |
| CHEMBL434142 | — | — | 1 | 9.70 |
| CHEMBL360134 | — | — | 1 | 9.60 |
| CHEMBL185572 | — | — | 1 | 9.00 |
| CHEMBL185182 | — | — | 1 | 9.00 |
| CHEMBL185007 | — | — | 1 | 8.90 |
| CHEMBL365613 | — | — | 1 | 8.90 |
| CHEMBL359655 | — | — | 1 | 8.90 |
| CHEMBL185133 | — | — | 1 | 8.80 |
| CHEMBL360721 | — | — | 1 | 8.70 |
| CHEMBL367348 | — | — | 1 | 8.70 |
| CHEMBL359903 | — | — | 1 | 8.60 |
| CHEMBL185452 | — | — | 1 | 8.50 |
| CHEMBL180049 | — | — | 1 | 8.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434548 | — | Kd | = | 0.07943 | nM | 10.10 |
| CHEMBL367815 | — | Kd | = | 0.1995 | nM | 9.70 |
| CHEMBL434142 | — | Kd | = | 0.1995 | nM | 9.70 |
| CHEMBL360134 | — | Kd | = | 0.2512 | nM | 9.60 |
| CHEMBL185572 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL185182 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL185007 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL365613 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL359655 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL185133 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL360721 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL367348 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL359903 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL185452 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL180049 | — | Kd | = | 6.31 | nM | 8.20 |