Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL360134

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1

Basic Information

ChEMBL ID CHEMBL360134
Phase Preclinical
Structure Type MOL
InChI Key GCOOJVFHVKWCPG-HHHXNRCGSA-N
2
Targets
2
Activities
2
Assay Types
1
PK Parameters
3
Publications
0
Known Names

Molecular Properties

520.5
MW (Da)
4.98
ALogP
4
HBA
0
HBD
36.0
PSA (Ų)
0.51
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H39Cl2N3O2
MW 520.55
Aromatic Rings 1
Heavy Atoms 35
NP-Likeness -0.23

Activity Summary

Kd 1 meas. best 9.6
Ki 1 meas. best 5.02

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Substance-K receptor
CHEMBL3433
Kd 9.6 9.6 0.3 1
Substance-K receptor
CHEMBL2327
Ki 5.02 5.02 9500.0 1

Pharmacokinetic Data

Parameter Value Units Species
T1/2 0.01667 hr Homo sapiens

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Substance-K receptor Kd = 0.2512 nM 9.6 pA2 for NK2 receptor of rabbit pulmonary artery 16039119
Substance-K receptor Ki = 9500.0 nM 5.02 Ki for human Neurokinin 2 receptor 16039119

Literature References

PubMed DOI Target Context # Activities
16039119 10.1016/j.bmcl.2005.05.134 Substance-K receptor 2
16039119 10.1016/j.bmcl.2005.05.134 Homo sapiens 2
16039119 10.1016/j.bmcl.2005.05.134 No relevant target 1

Data from ChEMBL 36 via Core Engine