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Assay Detail

CHEMBL835448

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
pA2 for NK2 receptor of human bladder IM9 cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type IM-9
Confidence 9 — Direct single protein target
Curated By Expert

Target

Substance-K receptor (CHEMBL2327)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-activity relationships of 1-alkyl-5-(3,4-dichlorophenyl)-5-{2-[3-(substituted)-1-azetidinyl]-ethyl}-2-piperidones. Part 2: Improving oral absorption.
Middleton DS, MacKenzie AR, Newman SD, Corless M, Warren A, Marchington AP, Jones B.
Bioorg Med Chem Lett (2005) 15 : 3957 -3961
PubMed 16039119 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 9.20 9.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL182600 1 9.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL182600 Kd = 0.631 nM 9.20