Assay Detail
Functional
CHEMBL835744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of beta-arrestin translocation at human chemoattractant receptor-homologous molecule expressed on TH2 cells in BRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TH2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.08 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179036 | — | — | 1 | 8.52 |
| CHEMBL194085 | — | — | 1 | 8.42 |
| CHEMBL373118 | — | — | 1 | 7.82 |
| CHEMBL361812 | RAMATROBAN | 4.0 | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179036 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL194085 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL373118 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL361812 | RAMATROBAN | IC50 | = | 28.0 | nM | 7.55 |