Assay Detail
Functional
CHEMBL835862
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Inhibitory concentration that inhibits 50% of the growth of Namalwa MDR Burkitts lymphoma MDR cell carcinoma cell line after 72 hr of drug exposure.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | carcinoma cell line |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.02 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364622 | — | — | 1 | 9.19 |
| CHEMBL414281 | — | — | 1 | 9.05 |
| CHEMBL433958 | — | — | 1 | 8.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364622 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL414281 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL433958 | — | IC50 | = | 1.5 | nM | 8.82 |