Assay Detail
Functional
CHEMBL836613
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to relax KCl induced rat aorta ring contractions by 50% upon incubation with the compound at 37 degree C for 90 mins
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: effect of 6,7-disubstitution on potency and tissue selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 4.92 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361271 | — | — | 1 | 6.00 |
| CHEMBL188658 | — | — | 1 | 5.92 |
| CHEMBL363989 | — | — | 1 | 5.64 |
| CHEMBL365122 | — | — | 1 | 5.48 |
| CHEMBL188407 | — | — | 1 | 5.33 |
| CHEMBL326708 | — | — | 1 | 5.32 |
| CHEMBL361944 | — | — | 1 | 5.25 |
| CHEMBL188027 | — | — | 1 | 5.18 |
| CHEMBL189909 | — | — | 1 | 5.09 |
| CHEMBL188213 | — | — | 1 | 4.90 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.65 |
| CHEMBL191047 | — | — | 1 | 4.63 |
| CHEMBL112668 | — | — | 1 | 4.44 |
| CHEMBL191539 | — | — | 1 | 4.43 |
| CHEMBL187887 | — | — | 1 | 4.40 |
| CHEMBL191182 | — | — | 1 | 4.38 |
| CHEMBL115565 | — | — | 1 | 4.37 |
| CHEMBL363991 | — | — | 1 | 4.37 |
| CHEMBL191282 | — | — | 1 | 4.34 |
| CHEMBL365570 | — | — | 1 | 4.18 |
| CHEMBL190114 | — | — | 1 | - |
| CHEMBL364639 | — | — | 1 | - |
| CHEMBL372025 | — | — | 1 | - |
| CHEMBL188208 | — | — | 1 | - |
| CHEMBL189093 | — | — | 1 | - |
| CHEMBL190957 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361271 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL188658 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL363989 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL365122 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL188407 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL326708 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL361944 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL188027 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL189909 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL188213 | — | EC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL181 | DIAZOXIDE | EC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL191047 | — | EC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL112668 | — | EC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL191539 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL187887 | — | EC50 | = | 39900.0 | nM | 4.40 |
| CHEMBL191182 | — | EC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL115565 | — | EC50 | = | 43100.0 | nM | 4.37 |
| CHEMBL363991 | — | EC50 | = | 42400.0 | nM | 4.37 |
| CHEMBL191282 | — | EC50 | = | 45300.0 | nM | 4.34 |
| CHEMBL365570 | — | EC50 | = | 66700.0 | nM | 4.18 |
| CHEMBL190114 | — | EC50 | = | 200000.0 | nM | - |
| CHEMBL364639 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL372025 | — | EC50 | = | 102400.0 | nM | - |
| CHEMBL188208 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL189093 | — | EC50 | = | 274000.0 | nM | - |
| CHEMBL190957 | — | EC50 | > | 30000.0 | nM | - |