Assay Detail
Functional
CHEMBL836808
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Inhibitory activity against IFN-gamma production (Anti-CD3 monoclonal antibody stimulated and cultured CD4 positive cells purified from human peripheral blood mononuclear cell)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CD4 positive |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.73 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411735 | — | — | 1 | 10.52 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 10.22 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 1 | 9.49 |
| CHEMBL265123 | — | — | 1 | 8.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411735 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL1370 | BUDESONIDE | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL265123 | — | IC50 | = | 2.13 | nM | 8.67 |