Assay Detail
Functional
CHEMBL837198
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Melanin-concentrating hormone (MCH) mediated [Ca2+] release in IMR-32 cells
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor (CHEMBL2111437) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.31 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179501 | — | — | 1 | 7.96 |
| CHEMBL426292 | — | — | 1 | 6.98 |
| CHEMBL196599 | — | — | 1 | 6.83 |
| CHEMBL197054 | — | — | 1 | 6.77 |
| CHEMBL195319 | — | — | 1 | 6.75 |
| CHEMBL197210 | — | — | 1 | 6.56 |
| CHEMBL364071 | — | — | 1 | 6.29 |
| CHEMBL196839 | — | — | 1 | 6.20 |
| CHEMBL195914 | — | — | 1 | 6.18 |
| CHEMBL196388 | — | — | 1 | 6.12 |
| CHEMBL424836 | — | — | 1 | 6.05 |
| CHEMBL425013 | — | — | 1 | 5.95 |
| CHEMBL196115 | — | — | 1 | 5.93 |
| CHEMBL193583 | — | — | 1 | 5.74 |
| CHEMBL197571 | — | — | 1 | 5.54 |
| CHEMBL372570 | — | — | 1 | 5.15 |
| CHEMBL196991 | — | — | 1 | - |
| CHEMBL425744 | — | — | 1 | - |
| CHEMBL383798 | — | — | 1 | - |
| CHEMBL196390 | — | — | 1 | - |
| CHEMBL196332 | — | — | 1 | - |
| CHEMBL196781 | — | — | 1 | - |
| CHEMBL370839 | — | — | 1 | - |
| CHEMBL364936 | — | — | 1 | - |
| CHEMBL195896 | — | — | 1 | - |
| CHEMBL372291 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179501 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL426292 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL196599 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL197054 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL195319 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL197210 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL364071 | — | IC50 | = | 516.0 | nM | 6.29 |
| CHEMBL196839 | — | IC50 | = | 626.0 | nM | 6.20 |
| CHEMBL195914 | — | IC50 | = | 654.0 | nM | 6.18 |
| CHEMBL196388 | — | IC50 | = | 751.0 | nM | 6.12 |
| CHEMBL424836 | — | IC50 | = | 894.0 | nM | 6.05 |
| CHEMBL425013 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL196115 | — | IC50 | = | 1177.0 | nM | 5.93 |
| CHEMBL193583 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL197571 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL372570 | — | IC50 | = | 7140.0 | nM | 5.15 |
| CHEMBL196991 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL425744 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL383798 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL196390 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL196332 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL196781 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL370839 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL364936 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL195896 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL372291 | — | IC50 | > | 10000.0 | nM | - |