Assay Detail
Functional
CHEMBL837254
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGF-dependent rat glioma cell proliferation
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor (PDGFr) (CHEMBL2111344) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.44 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189691 | — | — | 1 | 6.01 |
| CHEMBL425363 | — | — | 1 | 5.92 |
| CHEMBL190161 | — | — | 1 | 5.89 |
| CHEMBL192856 | — | — | 1 | 5.82 |
| CHEMBL189995 | — | — | 1 | 5.75 |
| CHEMBL278472 | — | — | 1 | 5.75 |
| CHEMBL191023 | — | — | 1 | 5.68 |
| CHEMBL187396 | — | — | 1 | 5.57 |
| CHEMBL191070 | — | — | 1 | 5.54 |
| CHEMBL365727 | — | — | 1 | 5.47 |
| CHEMBL190389 | — | — | 1 | 5.46 |
| CHEMBL363551 | — | — | 1 | 5.40 |
| CHEMBL188978 | — | — | 1 | 5.23 |
| CHEMBL188087 | — | — | 1 | 5.12 |
| CHEMBL189059 | — | — | 1 | 5.10 |
| CHEMBL191265 | — | — | 1 | 5.04 |
| CHEMBL365140 | — | — | 1 | 4.96 |
| CHEMBL189851 | — | — | 1 | 4.92 |
| CHEMBL189584 | PD-173074 | — | 1 | 4.77 |
| CHEMBL190783 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189691 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL425363 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL190161 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL192856 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL189995 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL278472 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL191023 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL187396 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL191070 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL365727 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL190389 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL363551 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL188978 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL188087 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL189059 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL191265 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL365140 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL189851 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL189584 | PD-173074 | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL190783 | — | IC50 | > | 25000.0 | nM | - |