Assay Detail
Functional
CHEMBL837262
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Inhibitory concentration to inhibit cell growth 50% was determined in HL60 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.66 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179973 | — | — | 1 | 7.00 |
| CHEMBL360027 | — | — | 1 | 6.60 |
| CHEMBL176195 | — | — | 1 | 6.52 |
| CHEMBL362070 | — | — | 1 | 6.30 |
| CHEMBL175773 | — | — | 1 | 6.05 |
| CHEMBL179381 | — | — | 1 | 5.82 |
| CHEMBL176004 | — | — | 1 | 5.70 |
| CHEMBL179772 | — | — | 1 | 5.70 |
| CHEMBL367070 | — | — | 1 | 5.52 |
| CHEMBL179156 | — | — | 1 | 5.52 |
| CHEMBL361743 | — | — | 1 | 5.50 |
| CHEMBL361644 | — | — | 1 | 5.30 |
| CHEMBL179051 | — | — | 1 | 4.92 |
| CHEMBL441671 | — | — | 1 | 4.82 |
| CHEMBL177304 | — | — | 1 | 4.70 |
| CHEMBL176005 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179973 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL360027 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL176195 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL362070 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL175773 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL179381 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL176004 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL179772 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL367070 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL179156 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL361743 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL361644 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL179051 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL441671 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL177304 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL176005 | — | IC50 | = | 30000.0 | nM | 4.52 |