Assay Detail
Functional
CHEMBL837264
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inhibitory concentration against PGE-2 production in LPS-stimulated RAW264.7 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E2 production in lipopolysaccharide-induced mouse macrophage cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.36 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188181 | 3,5-O-DIMETHYLPINOSYLVIN | — | 1 | 7.00 |
| CHEMBL186096 | — | — | 1 | 5.77 |
| CHEMBL187028 | — | — | 1 | 5.70 |
| CHEMBL186366 | PINOSYLVIN METHYL ETHER | — | 1 | 4.98 |
| CHEMBL101506 | PINOSYLVIN | — | 1 | 4.97 |
| CHEMBL470251 | — | — | 1 | 4.92 |
| CHEMBL142652 | PICEID | 2.0 | 1 | 4.87 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.68 |
| CHEMBL363534 | — | — | 1 | - |
| CHEMBL185074 | — | — | 1 | - |
| CHEMBL100687 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188181 | 3,5-O-DIMETHYLPINOSYLVIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL186096 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL187028 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL186366 | PINOSYLVIN METHYL ETHER | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL101506 | PINOSYLVIN | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL470251 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL142652 | PICEID | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL165 | RESVERATROL | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL363534 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL185074 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL100687 | — | IC50 | > | 50000.0 | nM | - |