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Assay Detail

CHEMBL837273

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Functional
Antiviral activity against human immunodeficiency virus type 1 by using MAGI assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: synthesis and biological activity.
Normand-Bayle M, Bénard C, Zouhiri F, Mouscadet JF, Leh H, Thomas CM, Mbemba G, Desmaële D, d'Angelo J.
Bioorg Med Chem Lett (2005) 15 : 4019 -4022
PubMed 16002283 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.23 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL190951 1 6.30
CHEMBL39092 1 6.00
CHEMBL187452 1 5.70
CHEMBL188293 1 5.70
CHEMBL188040 1 5.70
CHEMBL189715 1 5.40
CHEMBL189128 1 5.40
CHEMBL360650 1 5.30
CHEMBL188712 1 5.22
CHEMBL415771 1 4.46
CHEMBL185770 1 4.40
CHEMBL187564 1 4.22
CHEMBL187741 1 4.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL190951 IC50 = 500.0 nM 6.30
CHEMBL39092 IC50 = 1000.0 nM 6.00
CHEMBL187452 IC50 = 2000.0 nM 5.70
CHEMBL188293 IC50 = 2000.0 nM 5.70
CHEMBL188040 IC50 = 2000.0 nM 5.70
CHEMBL189715 IC50 = 4000.0 nM 5.40
CHEMBL189128 IC50 = 4000.0 nM 5.40
CHEMBL360650 IC50 = 5000.0 nM 5.30
CHEMBL188712 IC50 = 6000.0 nM 5.22
CHEMBL415771 IC50 = 35000.0 nM 4.46
CHEMBL185770 IC50 = 40000.0 nM 4.40
CHEMBL187564 IC50 = 60000.0 nM 4.22
CHEMBL187741 IC50 = 63000.0 nM 4.20