Assay Detail
Functional
CHEMBL837459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit cell proliferation in CPT-K5 tumor cell line; camptothecin resistant
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI 8402 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.11 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL187471 | — | — | 1 | 6.70 |
| CHEMBL186397 | — | — | 1 | 6.68 |
| CHEMBL184236 | — | — | 1 | 6.14 |
| CHEMBL186260 | — | — | 1 | 6.05 |
| CHEMBL70790 | — | — | 1 | 6.05 |
| CHEMBL184515 | — | — | 1 | 6.00 |
| CHEMBL186690 | — | — | 1 | 5.82 |
| CHEMBL361041 | — | — | 1 | 5.82 |
| CHEMBL187041 | — | — | 1 | 5.69 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | - |
| CHEMBL187426 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL187471 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL186397 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL184236 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL186260 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL70790 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL184515 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL186690 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL361041 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL187041 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL84 | TOPOTECAN | IC50 | > | 10000.0 | nM | - |
| CHEMBL187426 | — | IC50 | > | 10000.0 | nM | - |