Assay Detail
Functional
CHEMBL837463
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against HIV F227C mutant strain
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.37 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.87 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.80 |
| CHEMBL369697 | — | — | 1 | 6.65 |
| CHEMBL424772 | — | — | 1 | 6.63 |
| CHEMBL368039 | — | — | 1 | 6.47 |
| CHEMBL178689 | — | — | 1 | 6.20 |
| CHEMBL366692 | — | — | 1 | 6.20 |
| CHEMBL177275 | — | — | 1 | 6.10 |
| CHEMBL177666 | — | — | 1 | 6.10 |
| CHEMBL177709 | — | — | 1 | 6.06 |
| CHEMBL177563 | — | — | 1 | 5.95 |
| CHEMBL128569 | — | — | 1 | - |
| CHEMBL175692 | — | — | 1 | - |
| CHEMBL367745 | — | — | 1 | - |
| CHEMBL174536 | — | — | 1 | - |
| CHEMBL180008 | — | — | 1 | - |
| CHEMBL369599 | — | — | 1 | - |
| CHEMBL177744 | — | — | 1 | - |
| CHEMBL178043 | — | — | 1 | - |
| CHEMBL177253 | — | — | 1 | - |
| CHEMBL369148 | — | — | 1 | - |
| CHEMBL175873 | — | — | 1 | - |
| CHEMBL360957 | — | — | 1 | - |
| CHEMBL175655 | — | — | 1 | - |
| CHEMBL175534 | — | — | 1 | - |
| CHEMBL178061 | — | — | 1 | - |
| CHEMBL366811 | — | — | 1 | - |
| CHEMBL177491 | — | — | 1 | - |
| CHEMBL179736 | — | — | 1 | - |
| CHEMBL177383 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL369697 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL424772 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL368039 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL178689 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL366692 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL177275 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL177666 | — | IC50 | = | 794.0 | nM | 6.10 |
| CHEMBL177709 | — | IC50 | = | 869.0 | nM | 6.06 |
| CHEMBL177563 | — | IC50 | = | 1119.0 | nM | 5.95 |
| CHEMBL369599 | — | IC50 | = | - | nM | - |
| CHEMBL435522 | — | IC50 | = | - | nM | - |
| CHEMBL180008 | — | IC50 | = | - | nM | - |
| CHEMBL174536 | — | IC50 | = | - | nM | - |
| CHEMBL367745 | — | IC50 | = | - | nM | - |
| CHEMBL175692 | — | IC50 | = | - | nM | - |
| CHEMBL128569 | — | IC50 | = | - | nM | - |
| CHEMBL129144 | — | IC50 | = | - | nM | - |
| CHEMBL176107 | — | IC50 | = | - | nM | - |
| CHEMBL178936 | — | IC50 | = | - | nM | - |
| CHEMBL175925 | — | IC50 | = | - | nM | - |
| CHEMBL424972 | — | IC50 | = | - | nM | - |
| CHEMBL174339 | — | IC50 | = | - | nM | - |
| CHEMBL177744 | — | IC50 | = | - | nM | - |
| CHEMBL178043 | — | IC50 | = | - | nM | - |
| CHEMBL177253 | — | IC50 | = | - | nM | - |
| CHEMBL369148 | — | IC50 | = | - | nM | - |
| CHEMBL175873 | — | IC50 | = | - | nM | - |
| CHEMBL360957 | — | IC50 | = | - | nM | - |
| CHEMBL175655 | — | IC50 | = | - | nM | - |
| CHEMBL175534 | — | IC50 | = | - | nM | - |
| CHEMBL178061 | — | IC50 | = | - | nM | - |
| CHEMBL366811 | — | IC50 | = | - | nM | - |
| CHEMBL177491 | — | IC50 | = | - | nM | - |
| CHEMBL179736 | — | IC50 | = | - | nM | - |
| CHEMBL177383 | — | IC50 | = | - | nM | - |