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Assay Detail

CHEMBL837478

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration was measured against chinese hamster ovary (CHO-MG) cell line
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cricetulus griseus
Cell Type CHO-MG
Confidence 1 — Organism
Curated By Intermediate

Target

CHO-MG (CHEMBL614558)
Type CELL-LINE
Organism Cricetulus griseus

Publication

N1-substituent effects in the selective delivery of polyamine conjugates into cells containing active polyamine transporters.
Gardner RA, Delcros JG, Konate F, Breitbeil F, Martin B, Sigman M, Huang M, Phanstiel O.
J Med Chem (2004) 47 : 6055 -6069
PubMed 15537360 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.63 5.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL537852 1 5.92
CHEMBL558390 1 5.12
CHEMBL555288 1 4.95
CHEMBL536725 1 4.81
CHEMBL536041 1 4.48
CHEMBL535594 1 4.47
CHEMBL535370 1 4.42
CHEMBL536273 1 4.29
CHEMBL535821 1 4.24
CHEMBL541629 1 4.18
CHEMBL537630 1 4.06
CHEMBL538321 1 -
CHEMBL535603 1 -
CHEMBL556559 1 -
CHEMBL536492 1 -
CHEMBL540098 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL537852 IC50 = 1200.0 nM 5.92
CHEMBL558390 IC50 = 7600.0 nM 5.12
CHEMBL555288 IC50 = 11200.0 nM 4.95
CHEMBL536725 IC50 = 15500.0 nM 4.81
CHEMBL536041 IC50 = 33200.0 nM 4.48
CHEMBL535594 IC50 = 33500.0 nM 4.47
CHEMBL535370 IC50 = 38200.0 nM 4.42
CHEMBL536273 IC50 = 51300.0 nM 4.29
CHEMBL535821 IC50 = 57300.0 nM 4.24
CHEMBL541629 IC50 = 66700.0 nM 4.18
CHEMBL537630 IC50 = 86600.0 nM 4.06
CHEMBL538321 IC50 > 1000000.0 nM -
CHEMBL535603 IC50 > 100000.0 nM -
CHEMBL556559 IC50 = 106100.0 nM -
CHEMBL536492 IC50 > 500000.0 nM -
CHEMBL540098 IC50 = 130800.0 nM -