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Assay Detail

CHEMBL837530

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against HL-60 (human fibrosarcoma) cell line; Range 0.4-16 uM
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Intermediate

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and photochemotherapeutic activity of thiopyrano[2,3-e]indol-2-ones.
Barraja P, Sciabica L, Diana P, Lauria A, Montalbano A, Almerico AM, Dattolo G, Cirrincione G, Disarò S, Basso G, Viola G, Dall'Acqua F.
Bioorg Med Chem Lett (2005) 15 : 2291 -2294
PubMed 15837311 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.80 4.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL164660 PSORALEN 1.0 1 4.80
CHEMBL53569 ANGELICIN 1 4.80
CHEMBL193926 1 4.80
CHEMBL196349 1 4.80
CHEMBL371331 1 4.80
CHEMBL196144 1 4.80
CHEMBL197360 1 4.80
CHEMBL197365 1 4.80
CHEMBL427005 1 4.80
CHEMBL373200 1 4.80
CHEMBL427176 1 4.80
CHEMBL197160 1 4.80
CHEMBL195590 1 4.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL164660 PSORALEN IC50 = 16000.0 nM 4.80
CHEMBL53569 ANGELICIN IC50 = 16000.0 nM 4.80
CHEMBL193926 IC50 = 16000.0 nM 4.80
CHEMBL196349 IC50 = 16000.0 nM 4.80
CHEMBL371331 IC50 = 16000.0 nM 4.80
CHEMBL196144 IC50 = 16000.0 nM 4.80
CHEMBL197360 IC50 = 16000.0 nM 4.80
CHEMBL197365 IC50 = 16000.0 nM 4.80
CHEMBL427005 IC50 = 16000.0 nM 4.80
CHEMBL373200 IC50 = 16000.0 nM 4.80
CHEMBL427176 IC50 = 16000.0 nM 4.80
CHEMBL197160 IC50 = 16000.0 nM 4.80
CHEMBL195590 IC50 = 16000.0 nM 4.80