Assay Detail
ADMET
CHEMBL837542
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Cytotoxicity against doxorubicin resistant LoVo cell line was determined against 1 hour
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Rational design, synthesis, and biological evaluation of bis(pyrimido[5,6,1-de]acridines) and bis(pyrazolo[3,4,5-kl]acridine-5-carboxamides) as new anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.29 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188103 | — | — | 1 | 7.12 |
| CHEMBL186004 | — | — | 1 | 6.42 |
| CHEMBL187738 | — | — | 1 | 6.09 |
| CHEMBL189214 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188103 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL186004 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL187738 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL189214 | — | IC50 | = | 3100.0 | nM | 5.51 |