Assay Detail
Functional
CHEMBL837592
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against [3H]-DA uptake in rat brain tissue
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of meperidine analogues at monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.56 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1701 | MEPERIDINE HYDROCHLORIDE | 4.0 | 2 | 6.21 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1701 | MEPERIDINE HYDROCHLORIDE | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1701 | MEPERIDINE HYDROCHLORIDE | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL370805 | COCAINE | IC50 | = | 405000.0 | nM | - |