Assay Detail
Functional
CHEMBL837596
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit TNF-alpha production was determined in human whole blood
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.32 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361431 | — | — | 1 | 6.52 |
| CHEMBL184725 | — | — | 1 | 6.39 |
| CHEMBL185315 | — | — | 1 | 6.30 |
| CHEMBL365614 | — | — | 1 | 5.96 |
| CHEMBL10 | SB-203580 | — | 1 | 5.70 |
| CHEMBL186665 | — | — | 1 | 5.50 |
| CHEMBL187857 | — | — | 1 | 5.47 |
| CHEMBL363462 | — | — | 1 | 5.46 |
| CHEMBL362902 | — | — | 1 | 5.43 |
| CHEMBL188167 | — | — | 1 | 5.34 |
| CHEMBL366080 | — | — | 1 | 5.28 |
| CHEMBL184659 | — | — | 1 | 5.20 |
| CHEMBL188114 | — | — | 1 | 5.16 |
| CHEMBL184271 | — | — | 1 | 5.11 |
| CHEMBL185328 | — | — | 1 | 4.96 |
| CHEMBL426969 | — | — | 1 | 4.80 |
| CHEMBL184052 | — | — | 1 | 4.80 |
| CHEMBL184555 | — | — | 1 | 4.68 |
| CHEMBL188126 | — | — | 1 | 4.64 |
| CHEMBL185162 | — | — | 1 | 4.57 |
| CHEMBL364576 | — | — | 1 | 4.46 |
| CHEMBL185567 | — | — | 1 | - |
| CHEMBL182772 | — | — | 1 | - |
| CHEMBL7917 | TYRPHOSTIN AG-1478 | — | 1 | - |
| CHEMBL359797 | — | — | 1 | - |
| CHEMBL184257 | — | — | 1 | - |
| CHEMBL186852 | — | — | 1 | - |
| CHEMBL186802 | — | — | 1 | - |
| CHEMBL184682 | — | — | 1 | - |
| CHEMBL187007 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361431 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL184725 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL185315 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL365614 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL10 | SB-203580 | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL186665 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL187857 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL363462 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL362902 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL188167 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL366080 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL184659 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL188114 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL184271 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL185328 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL426969 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL184052 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL184555 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL188126 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL185162 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL364576 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL186580 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL185327 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL184685 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL186747 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL182397 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL360209 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL365830 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL187007 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL184682 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL186802 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL186852 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL184257 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL359797 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL7917 | TYRPHOSTIN AG-1478 | IC50 | > | 50000.0 | nM | - |
| CHEMBL182772 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL185567 | — | IC50 | > | 50000.0 | nM | - |