Assay Detail
Functional
CHEMBL837822
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Antagonistic activity against 5 nM Dexamethasone induced glucocorticoid receptor mediated alkaline phosphatase activity
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Antidiabetic activity of passive nonsteroidal glucocorticoid receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.93 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 8.32 |
| CHEMBL363151 | — | — | 1 | 7.37 |
| CHEMBL185265 | — | — | 1 | 7.07 |
| CHEMBL190225 | — | — | 1 | 6.59 |
| CHEMBL191042 | — | — | 1 | 6.48 |
| CHEMBL191423 | — | — | 1 | 6.36 |
| CHEMBL190109 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL363151 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL185265 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL190225 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL191042 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL191423 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL190109 | — | IC50 | = | 500.0 | nM | 6.30 |