Assay Detail
Functional
CHEMBL837920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against cycloheximide induced cell death in human white blood cells in the presence of plasma proteins
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.04 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179503 | — | — | 1 | 6.16 |
| CHEMBL366927 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179503 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL366927 | — | IC50 | = | 1200.0 | nM | 5.92 |