Assay Detail
Binding
CHEMBL838508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant against human alpha thrombin
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.47 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270437 | — | — | 1 | 9.74 |
| CHEMBL368937 | — | — | 1 | 9.74 |
| CHEMBL176491 | — | — | 1 | 8.70 |
| CHEMBL179210 | — | — | 1 | 8.51 |
| CHEMBL361379 | — | — | 1 | 8.00 |
| CHEMBL273196 | EFEGATRAN | 2.0 | 1 | 7.75 |
| CHEMBL176063 | — | — | 1 | 7.68 |
| CHEMBL435514 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270437 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL368937 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL176491 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL179210 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL361379 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL273196 | EFEGATRAN | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL176063 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL435514 | — | Ki | = | 24.0 | nM | 7.62 |