Assay Detail
Binding
CHEMBL838685
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Binding affinity towards alpha-Mannosidase isolated from Jack bean
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canavalia ensiformis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Functionalized pyrrolidines inhibit alpha-mannosidase activity and growth of human glioblastoma and melanoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.89 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425723 | — | — | 1 | 6.87 |
| CHEMBL190736 | — | — | 1 | 5.92 |
| CHEMBL425364 | — | — | 1 | 5.87 |
| CHEMBL190634 | — | — | 1 | 5.64 |
| CHEMBL363475 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425723 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL190736 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL425364 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL190634 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL363475 | — | Ki | = | 7400.0 | nM | 5.13 |