Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL838688

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards mycobacterium tuberculosis thymidine monophosphate kinase
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mycobacterium tuberculosis
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Thymidylate kinase (CHEMBL2361)
Type SINGLE PROTEIN
Organism Mycobacterium tuberculosis

Publication

LEA3D: a computer-aided ligand design for structure-based drug design.
Douguet D, Munier-Lehmann H, Labesse G, Pochet S.
J Med Chem (2005) 48 : 2457 -2468
PubMed 15801836 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 4.39 4.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL189878 1 4.91
CHEMBL193779 1 4.78
CHEMBL52609 DOXRIBTIMINE 2.0 1 4.57
CHEMBL190125 1 4.50
CHEMBL189057 1 4.42
CHEMBL190145 1 4.36
CHEMBL190912 1 4.36
CHEMBL193948 1 4.35
CHEMBL190616 1 4.30
CHEMBL365098 1 4.17
CHEMBL189636 1 4.17
CHEMBL365123 1 4.12
CHEMBL189491 1 4.05
CHEMBL370674 1 -
CHEMBL373302 1 -
CHEMBL414848 1 -
CHEMBL191010 1 -
CHEMBL364887 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL189878 Ki = 12300.0 nM 4.91
CHEMBL193779 Ki = 16500.0 nM 4.78
CHEMBL52609 DOXRIBTIMINE Ki = 27000.0 nM 4.57
CHEMBL190125 Ki = 32000.0 nM 4.50
CHEMBL189057 Ki = 38000.0 nM 4.42
CHEMBL190145 Ki = 44000.0 nM 4.36
CHEMBL190912 Ki = 44000.0 nM 4.36
CHEMBL193948 Ki = 45000.0 nM 4.35
CHEMBL190616 Ki = 50000.0 nM 4.30
CHEMBL365098 Ki = 67000.0 nM 4.17
CHEMBL189636 Ki = 68000.0 nM 4.17
CHEMBL365123 Ki = 75000.0 nM 4.12
CHEMBL189491 Ki = 90000.0 nM 4.05
CHEMBL370674 Ki = 980000.0 nM -
CHEMBL373302 Ki = 810000.0 nM -
CHEMBL414848 Ki = 240000.0 nM -
CHEMBL191010 Ki = 265000.0 nM -
CHEMBL364887 Ki = 110000.0 nM -