Assay Detail
Binding
CHEMBL838689
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CIT from dopamine transporter of rat striatal homogenate
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.73 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97887 | — | — | 1 | 9.52 |
| CHEMBL187299 | — | — | 1 | 9.28 |
| CHEMBL365623 | — | — | 1 | 9.28 |
| CHEMBL186119 | — | — | 1 | 9.24 |
| CHEMBL184807 | — | — | 1 | 9.14 |
| CHEMBL186306 | — | — | 1 | 9.07 |
| CHEMBL318961 | — | — | 1 | 9.03 |
| CHEMBL362565 | — | — | 1 | 8.91 |
| CHEMBL365649 | — | — | 1 | 8.72 |
| CHEMBL185608 | — | — | 1 | 8.63 |
| CHEMBL433159 | — | — | 1 | 8.48 |
| CHEMBL184123 | — | — | 1 | 7.97 |
| CHEMBL365413 | — | — | 1 | 7.59 |
| CHEMBL183259 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97887 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL187299 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL365623 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL186119 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL184807 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL186306 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL318961 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL362565 | — | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL365649 | — | Ki | = | 1.91 | nM | 8.72 |
| CHEMBL185608 | — | Ki | = | 2.33 | nM | 8.63 |
| CHEMBL433159 | — | Ki | = | 3.33 | nM | 8.48 |
| CHEMBL184123 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL365413 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL183259 | — | Ki | = | 44.5 | nM | 7.35 |