Assay Detail
Binding
CHEMBL838690
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Binding affinity against alpha 2 adrenergic receptor in rat cortex using [3H]clonidine as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.08 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41487 | — | — | 1 | 6.00 |
| CHEMBL361749 | — | — | 1 | 5.89 |
| CHEMBL185233 | — | — | 1 | 5.32 |
| CHEMBL59441 | — | — | 1 | 4.72 |
| CHEMBL182970 | — | — | 1 | 4.34 |
| CHEMBL182774 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41487 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL361749 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL185233 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL59441 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL182970 | — | Ki | = | 46000.0 | nM | 4.34 |
| CHEMBL182774 | — | Ki | = | 59000.0 | nM | 4.23 |