Assay Detail
Binding
CHEMBL838824
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Inhibition constant against rabbit liver carboxylesterase using CPT-11
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.30 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362996 | — | — | 1 | 7.85 |
| CHEMBL191847 | — | — | 1 | 7.62 |
| CHEMBL193228 | — | — | 1 | 7.60 |
| CHEMBL192139 | — | — | 1 | 7.37 |
| CHEMBL192180 | — | — | 1 | 7.28 |
| CHEMBL189886 | BENZIL | — | 1 | 6.73 |
| CHEMBL193140 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362996 | — | Ki | = | 14.1 | nM | 7.85 |
| CHEMBL191847 | — | Ki | = | 24.1 | nM | 7.62 |
| CHEMBL193228 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL192139 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL192180 | — | Ki | = | 52.5 | nM | 7.28 |
| CHEMBL189886 | BENZIL | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL193140 | — | Ki | = | 240.0 | nM | 6.62 |