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Assay Detail

CHEMBL838826

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against human steroid sulfatase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Steryl-sulfatase (CHEMBL3559)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2-(1-adamantyl)-4-(thio)chromenone-6-carboxylic acids: potent reversible inhibitors of human steroid sulfatase.
Horvath A, Nussbaumer P, Wolff B, Billich A.
J Med Chem (2004) 47 : 4268 -4276
PubMed 15293998 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 5.98 6.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL147705 1 6.72
CHEMBL262050 1 6.68
CHEMBL184540 1 6.30
CHEMBL186816 1 6.28
CHEMBL122708 EMATE 1 6.17
CHEMBL188214 1 5.66
CHEMBL188128 1 5.50
CHEMBL364624 1 4.50
CHEMBL189863 1 -
CHEMBL185877 1 -
CHEMBL183996 1 -
CHEMBL361924 1 -
CHEMBL361700 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL147705 Ki = 190.0 nM 6.72
CHEMBL262050 Ki = 210.0 nM 6.68
CHEMBL184540 Ki = 500.0 nM 6.30
CHEMBL186816 Ki = 530.0 nM 6.28
CHEMBL122708 EMATE Ki = 670.0 nM 6.17
CHEMBL188214 Ki = 2200.0 nM 5.66
CHEMBL188128 Ki = 3200.0 nM 5.50
CHEMBL364624 Ki = 32000.0 nM 4.50
CHEMBL189863 Ki > 20000.0 nM -
CHEMBL185877 Ki > 50000.0 nM -
CHEMBL183996 Ki > 50000.0 nM -
CHEMBL361924 Ki > 50000.0 nM -
CHEMBL361700 Ki > 50000.0 nM -