Assay Detail
Binding
CHEMBL838856
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In vitro ability to displace the radioligand [3H]-OH-DPAT from binding to rat 5-hydroxytryptamine 1A receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The impact of spacer structure on 5-HT7 and 5-HT1A receptor affinity in the group of long-chain arylpiperazine ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.59 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8618 | NAN-190 | — | 1 | 9.22 |
| CHEMBL186334 | — | — | 1 | 8.30 |
| CHEMBL279841 | — | — | 1 | 8.19 |
| CHEMBL441313 | — | — | 1 | 8.10 |
| CHEMBL187270 | — | — | 1 | 7.82 |
| CHEMBL365412 | — | — | 1 | 7.54 |
| CHEMBL365201 | — | — | 1 | 7.11 |
| CHEMBL186734 | — | — | 1 | 6.80 |
| CHEMBL185988 | — | — | 1 | 6.39 |
| CHEMBL185936 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8618 | NAN-190 | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL186334 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL279841 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL441313 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL187270 | — | Ki | = | 15.2 | nM | 7.82 |
| CHEMBL365412 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL365201 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL186734 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL185988 | — | Ki | = | 405.0 | nM | 6.39 |
| CHEMBL185936 | — | Ki | = | 415.0 | nM | 6.38 |