Assay Detail
Binding
CHEMBL839158
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding inhibition constant was determined by inhibition of [125I]iodocyanopindolol binding to Beta-2 adrenergic receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tryptamine-based human beta3-adrenergic receptor agonists. Part 1: SAR studies of the 7-position of the indole ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.25 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361505 | — | — | 1 | 7.60 |
| CHEMBL184407 | — | — | 1 | 7.32 |
| CHEMBL185836 | — | — | 1 | 7.29 |
| CHEMBL188196 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361505 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL184407 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL185836 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL188196 | — | Ki | = | 160.0 | nM | 6.80 |