Assay Detail
Binding
CHEMBL839534
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human mast cell tryptase beta
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human beta-tryptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.07 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365062 | — | — | 1 | 8.89 |
| CHEMBL362874 | — | — | 1 | 8.82 |
| CHEMBL186730 | — | — | 1 | 8.37 |
| CHEMBL185752 | — | — | 1 | 7.23 |
| CHEMBL188068 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365062 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL362874 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL186730 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL185752 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL188068 | — | Ki | = | 88.0 | nM | 7.06 |