Assay Detail
Binding
CHEMBL839537
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Inhibition of [3H]QNB binding to muscarinic receptor of rat cortex
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 5.28 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371816 | — | — | 1 | 5.97 |
| CHEMBL195146 | — | — | 1 | 5.67 |
| CHEMBL194329 | — | — | 1 | 5.56 |
| CHEMBL2113081 | — | — | 1 | 5.55 |
| CHEMBL2113083 | — | — | 1 | 5.47 |
| CHEMBL195475 | — | — | 1 | 5.39 |
| CHEMBL195138 | — | — | 1 | 5.15 |
| CHEMBL194439 | — | — | 1 | 5.15 |
| CHEMBL194024 | — | — | 1 | 4.92 |
| CHEMBL193806 | — | — | 1 | 4.87 |
| CHEMBL365519 | — | — | 1 | 4.86 |
| CHEMBL371679 | — | — | 1 | 4.82 |
| CHEMBL371349 | — | — | 1 | - |
| CHEMBL195404 | — | — | 1 | - |
| CHEMBL195181 | — | — | 1 | - |
| CHEMBL195709 | — | — | 1 | - |
| CHEMBL371344 | — | — | 1 | - |
| CHEMBL334027 | — | — | 1 | - |
| CHEMBL363189 | — | — | 1 | - |
| CHEMBL191985 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371816 | — | Ki | = | 1060.0 | nM | 5.97 |
| CHEMBL195146 | — | Ki | = | 2140.0 | nM | 5.67 |
| CHEMBL194329 | — | Ki | = | 2740.0 | nM | 5.56 |
| CHEMBL2113081 | — | Ki | = | 2830.0 | nM | 5.55 |
| CHEMBL2113083 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL195475 | — | Ki | = | 4060.0 | nM | 5.39 |
| CHEMBL195138 | — | Ki | = | 7060.0 | nM | 5.15 |
| CHEMBL194439 | — | Ki | = | 7090.0 | nM | 5.15 |
| CHEMBL194024 | — | Ki | = | 11900.0 | nM | 4.92 |
| CHEMBL193806 | — | Ki | = | 13500.0 | nM | 4.87 |
| CHEMBL365519 | — | Ki | = | 13900.0 | nM | 4.86 |
| CHEMBL371679 | — | Ki | = | 15100.0 | nM | 4.82 |
| CHEMBL371349 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL195404 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL195181 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL195709 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL371344 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL334027 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL363189 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL191985 | — | Ki | > | 10000.0 | nM | - |