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Assay Detail

CHEMBL839577

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against human Prostanoid TP receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Thromboxane A2 receptor (CHEMBL2069)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2,3-Diarylthiophenes as selective EP1 receptor antagonists.
Ducharme Y, Blouin M, Carrière MC, Chateauneuf A, Côté B, Denis D, Frenette R, Greig G, Kargman S, Lamontagne S, Martins E, Nantel F, O'Neill G, Sawyer N, Metters KM, Friesen RW.
Bioorg Med Chem Lett (2005) 15 : 1155 -1160
PubMed 15686932 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 6.64 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL362543 1 7.00
CHEMBL182368 1 6.92
CHEMBL362851 1 6.85
CHEMBL184779 1 6.82
CHEMBL182367 1 6.70
CHEMBL185346 1 6.66
CHEMBL184947 1 6.64
CHEMBL182623 1 6.44
CHEMBL2113029 1 6.41
CHEMBL360592 1 5.92
CHEMBL180046 1 -
CHEMBL182662 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL362543 Ki = 100.0 nM 7.00
CHEMBL182368 Ki = 120.0 nM 6.92
CHEMBL362851 Ki = 140.0 nM 6.85
CHEMBL184779 Ki = 150.0 nM 6.82
CHEMBL182367 Ki = 200.0 nM 6.70
CHEMBL185346 Ki = 220.0 nM 6.66
CHEMBL184947 Ki = 230.0 nM 6.64
CHEMBL182623 Ki = 360.0 nM 6.44
CHEMBL2113029 Ki = 390.0 nM 6.41
CHEMBL360592 Ki = 1200.0 nM 5.92
CHEMBL180046 Ki > 21000.0 nM -
CHEMBL182662 Ki > 21000.0 nM -