Assay Detail
Binding
CHEMBL839580
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Binding affinity for human 5-hydroxytryptamine 1A receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.52 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13647 | BMY-7378 | — | 1 | 9.34 |
| CHEMBL299691 | — | — | 1 | 8.12 |
| CHEMBL446180 | — | — | 1 | 7.62 |
| CHEMBL556313 | — | — | 1 | 7.60 |
| CHEMBL57546 | — | — | 1 | 7.27 |
| CHEMBL192099 | — | — | 1 | 7.26 |
| CHEMBL98241 | — | — | 1 | 6.52 |
| CHEMBL193620 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13647 | BMY-7378 | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL299691 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL446180 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL556313 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL57546 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL192099 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL98241 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL193620 | — | Ki | = | 360.0 | nM | 6.44 |