Assay Detail
Binding
CHEMBL839585
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against cytosolic human carbonic anhydrase I
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.32 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.51 |
| CHEMBL182429 | — | — | 1 | 7.10 |
| CHEMBL183701 | — | — | 1 | 7.03 |
| CHEMBL68257 | — | — | 1 | 6.98 |
| CHEMBL2113026 | — | — | 1 | 6.97 |
| CHEMBL182276 | — | — | 1 | 6.87 |
| CHEMBL182440 | — | — | 1 | 6.84 |
| CHEMBL183240 | — | — | 1 | 6.57 |
| CHEMBL182455 | — | — | 1 | 6.42 |
| CHEMBL353258 | — | — | 1 | 6.26 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.11 |
| CHEMBL181357 | — | — | 1 | 6.06 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.05 |
| CHEMBL171476 | — | — | 1 | 6.05 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL361421 | — | — | 1 | 5.87 |
| CHEMBL170139 | — | — | 1 | 5.19 |
| CHEMBL181753 | — | — | 1 | 4.78 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 4.30 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | - |
| CHEMBL221802 | — | — | 1 | - |
| CHEMBL360714 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL77517 | INDISULAM | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL182429 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL183701 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL68257 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL2113026 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL182276 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL182440 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL183240 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL182455 | — | Ki | = | 378.0 | nM | 6.42 |
| CHEMBL353258 | — | Ki | = | 548.0 | nM | 6.26 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL181357 | — | Ki | = | 872.0 | nM | 6.06 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL171476 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL361421 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL170139 | — | Ki | = | 6490.0 | nM | 5.19 |
| CHEMBL181753 | — | Ki | = | 16450.0 | nM | 4.78 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | - | nM | - | |
| CHEMBL221802 | — | Ki | = | 6000.0 | nM | - |
| CHEMBL360714 | — | Ki | > | 20.0 | nM | - |