Assay Detail
Binding
CHEMBL839609
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]ZM-241385 binding to human adenosine A2A receptor expressed in HeLa cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.60 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2096798 | — | — | 1 | 9.00 |
| CHEMBL361925 | — | — | 1 | 8.30 |
| CHEMBL360837 | — | — | 1 | 8.30 |
| CHEMBL368880 | — | — | 1 | 7.42 |
| CHEMBL186113 | GW-328267 | 1.0 | 1 | 7.34 |
| CHEMBL186403 | — | — | 1 | 7.32 |
| CHEMBL331372 | CGS-21680 | — | 1 | 7.30 |
| CHEMBL464859 | NECA | — | 1 | 6.89 |
| CHEMBL360646 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2096798 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL361925 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL360837 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL368880 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL186113 | GW-328267 | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL186403 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL331372 | CGS-21680 | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL464859 | NECA | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL360646 | — | Ki | = | 270.0 | nM | 6.57 |