Assay Detail
Binding
CHEMBL839635
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-341495 binding to membranes expressing recombinant human Metabotropic glutamate receptor 3
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.58 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8759 | EGLUMETAD | 2.0 | 1 | 7.03 |
| CHEMBL192977 | — | — | 1 | 6.84 |
| CHEMBL192051 | — | — | 2 | 6.52 |
| CHEMBL365368 | — | — | 1 | 6.29 |
| CHEMBL195500 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8759 | EGLUMETAD | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL192977 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL192051 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL365368 | — | Ki | = | 511.0 | nM | 6.29 |
| CHEMBL192051 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL195500 | — | Ki | > | 100000.0 | nM | - |