Assay Detail
Binding
CHEMBL839644
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 8.27 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192512 | — | — | 1 | 9.30 |
| CHEMBL421130 | — | — | 1 | 8.92 |
| CHEMBL33150 | — | — | 1 | 8.62 |
| CHEMBL370518 | — | — | 1 | 8.60 |
| CHEMBL34288 | — | — | 1 | 8.51 |
| CHEMBL370758 | — | — | 1 | 8.39 |
| CHEMBL33258 | — | — | 1 | 8.39 |
| CHEMBL366206 | — | — | 1 | 8.38 |
| CHEMBL427349 | — | — | 1 | 8.34 |
| CHEMBL445055 | — | — | 1 | 8.25 |
| CHEMBL2113057 | — | — | 1 | 8.21 |
| CHEMBL192875 | — | — | 1 | 8.20 |
| CHEMBL426639 | — | — | 1 | 8.19 |
| CHEMBL285066 | — | — | 1 | 8.17 |
| CHEMBL34287 | — | — | 1 | 8.03 |
| CHEMBL364241 | — | — | 1 | 8.02 |
| CHEMBL430914 | — | — | 1 | 7.98 |
| CHEMBL372014 | — | — | 1 | 7.94 |
| CHEMBL192750 | — | — | 1 | 7.91 |
| CHEMBL190284 | — | — | 1 | 7.82 |
| CHEMBL416266 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192512 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL421130 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL33150 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL370518 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL34288 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL370758 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL33258 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL366206 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL427349 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL445055 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL2113057 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL192875 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL426639 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL285066 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL34287 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL364241 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL430914 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL372014 | — | Ki | = | 11.6 | nM | 7.94 |
| CHEMBL192750 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL190284 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL416266 | — | Ki | = | 27.0 | nM | 7.57 |