Assay Detail
Binding
CHEMBL839667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Acyclic cyanamide-based inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.33 | 10.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371420 | — | — | 1 | 10.72 |
| CHEMBL191558 | — | — | 1 | 10.49 |
| CHEMBL189149 | — | — | 1 | 7.58 |
| CHEMBL362925 | — | — | 1 | 7.21 |
| CHEMBL370529 | — | — | 1 | 6.08 |
| CHEMBL192604 | — | — | 1 | 5.82 |
| CHEMBL189842 | — | — | 1 | 5.64 |
| CHEMBL191367 | — | — | 1 | 5.10 |
| CHEMBL433967 | — | — | 1 | - |
| CHEMBL190063 | — | — | 1 | - |
| CHEMBL192995 | — | — | 1 | - |
| CHEMBL193095 | — | — | 1 | - |
| CHEMBL190831 | — | — | 1 | - |
| CHEMBL190544 | — | — | 1 | - |
| CHEMBL190121 | — | — | 1 | - |
| CHEMBL190864 | — | — | 1 | - |
| CHEMBL189891 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371420 | — | Ki | = | 0.019 | nM | 10.72 |
| CHEMBL191558 | — | Ki | = | 0.032 | nM | 10.49 |
| CHEMBL189149 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL362925 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL370529 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL192604 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL189842 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL191367 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL433967 | — | Ki | = | 0.006 | nM | - |
| CHEMBL190063 | — | Ki | = | 0.007 | nM | - |
| CHEMBL192995 | — | Ki | = | 0.004 | nM | - |
| CHEMBL193095 | — | Ki | = | 0.004 | nM | - |
| CHEMBL190831 | — | Ki | > | 13000.0 | nM | - |
| CHEMBL190544 | — | Ki | = | 0.003 | nM | - |
| CHEMBL190121 | — | Ki | = | 0.009 | nM | - |
| CHEMBL190864 | — | Ki | > | 13000.0 | nM | - |
| CHEMBL189891 | — | Ki | > | 13000.0 | nM | - |