Assay Detail
Binding
CHEMBL839685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant against human intestinal carboxylesterase 2 (hiCE) using o-NPA (nitrophenyl acetate) as substrate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.88 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193140 | — | — | 1 | 8.39 |
| CHEMBL362996 | — | — | 1 | 8.25 |
| CHEMBL191847 | — | — | 1 | 8.10 |
| CHEMBL189886 | BENZIL | — | 1 | 7.83 |
| CHEMBL192180 | — | — | 1 | 7.74 |
| CHEMBL192139 | — | — | 1 | 6.97 |
| CHEMBL193228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193140 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL362996 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL191847 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL189886 | BENZIL | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL192180 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL192139 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL193228 | — | Ki | > | 100000.0 | nM | - |